Mini-Reviews in Medicinal Chemistry BX471: A CCR1 Antagonist with Anti-Inflammatory Activity in Man Mini-Reviews in Medicinal Chemistry Emerging Peptide Therapeutics for Inflammatory Autoimmune DiseasesĬurrent Pharmaceutical Design Thiol-Dependent Cathepsins: Pathophysiological Implications and Recent Advances in Inhibitor DesignĬurrent Pharmaceutical Design Gene Therapy Strategies Towards Immune Tolerance to Treat the Autoimmune DiseasesĬurrent Gene Therapy Some Important Dietary Polyphenolic Compounds: An Anti-inflammatory and Immunoregulatory Perspective Recent Patents on Inflammation & Allergy Drug Discovery Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System Mini-Reviews in Medicinal Chemistry Apoptosis: Potential Therapeutic Targets for New Drug DiscoveryĬurrent Medicinal Chemistry Cellular and Molecular Mechanisms Involved in the Action of Vitamin D Analogs Targeting Vitiligo DepigmentationĬurrent Drug Targets Neuropeptide - Adipose Tissue Communication and Intestinal PathophysiologyĬurrent Pharmaceutical Design Anti-Inflammatory Approaches that Target the Chemokine Network The Cancer Hygiene Hypothesis: From Theory to Therapeutic HelminthsĬurrent Cancer Therapy Reviews Anti-TNF-α Antibody Therapies in Autoimmune DiseasesĬurrent Topics in Medicinal Chemistry Azathioprine in Multiple Sclerosis Neurodegenerative Diseases Department, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City,MexicoĪbstract: Introduction: Neuromyelitis optica (NMO) and Multiple Sclerosis (MS) have been reported.Garci, Julio Granados, Thalia Sanchez, Lourdes Mena-Hernandez and Teresa Corona* Alonso, Jose de Jesus Flores Rivera, Yamel R. Title:Neuromyelitis Optica (NMO IgG+) and Genetic Susceptibility, Potential Ethnic InfluencesĪuthor(s): Veronica R. Keywords: Anti AQP4 antibody, HLA, Neuromyelitis Optica (NMO), Multiple Sclerosis (MS), Optic Neuritis (ON), Transverse That implicated immune-genetics as a key factor in development of this type of disease. These findings may support the hypothesis Than in controls (n=198 p=0.03 and 0.005, respectively).Ĭonclusion: There were no differences in the other alleles that have been described in MS subjects, The presence of HLA-DRB1*03 and HLA-DRB1*10 alleles were more frequent in NMO patients The mean age of the patients was 43.3 years old (20-67), and 80 percent of the patients were women. Result: We included 35 patients with an NMO diagnosis according to the Wingerchuk 2006 criteria. Involved in the susceptibility to develop NMO in a Mexican population. Materials and Methods: We performed a study with the main objective of identifying candidate genes Protein, the CTLA-4 gene, and the interleukin-1 gene. Such as those involved in the synthesis of the T cell beta chain receptor, the VH2-5 gene, myelin basic In this context, various genes have been studied, Role in the development of this type of disease. The genetics of NMO, epidemiological findings suggest that a polygenic background has an important NMO has a multifactorial origin (i.e., genetics, environmental and infectious factors). That NMO patients have a mainly European ancestry background. NMO is more frequent in non-Caucasians, and clinical phenotype differencesīetween populations are likely influenced by genetic susceptibility. Introduction: Neuromyelitis optica (NMO) and Multiple Sclerosis (MS) have been reported

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